个人简介
乔建军，教授
jianjunq@tju.edu.cn
研究方向：微生物合成生物学
乔建军，天津大学合成生物与生物制造学院教授，博士生导师，国家重点研发计划项目首席科学家。天津大学英才教授。国家“万人计划”科技创新领军人才。天津大学 A 类讲席教授。教育部新世纪人才。绍兴“名士之乡”英才计划创新人才 A 类。
长期致力于应用微生物合成生物学技术实现营养健康的相关研究。应用基因编辑技术、关键酶改造技术、菌群合成生物学技术等提升微生物高效合成天然产物的能力，重点开展倍半萜、多肽等天然产物的研究。利用微生物高效合成绿色生物农药、绿色食品添加剂、营养品等营养健康相关的产品；同时开展功能益生菌的筛选、构建、生产工艺开发等相关研究。
主持项目
先后主持两项国家重点研发计划项目。主持完成国家基金及省部级项目十余项。主持完成国家合成生物学研究重大863项目子课题。
代表性论文：
1. Wu S, Feng J, Liu C, Wu H, Qiu Z, Ge J, Sun S, Hong X, Li Y, Wang X, Yang A, Guo F, Qiao J*. Machine learning aided construction of the quorum sensing communication network for human gut microbiota. Nature Communications. 2022 Jun 2;13(1):3079.
2. Yan X, Zhou J, Ge J, Qiao J*, et al. Computer-Informed Engineering: A New Class I Sesquiterpene Synthase JeSTS4 for the Synthesis of an Unusual C10-(S)-Bicyclogermacrene. ACS catalysis, 2022(7):12.
3. Chen R, Wang S, Nie S, Qiao J* et al. Efcient Biosynthesis of the Plant-Derived Diterpenoid Miltiradiene in Saccharomyces cerevisiae. ACS Sustainable Chemistry & Engineering, 2025 (18):13.
4. Li Y, Li R, Ge X, Qiao J.* et al. Comprehensive Engineering Strategies for Heterologous Production of Zealexin A1 in Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 2024, 72(34):19071-19080.
5. Wu S, Zhang H, Zhou Y, Xu C, Yuan B, Wang H, Chen D, Liu C, Caiyin Q, Wu H, Yang A, Zhao K, Qiao J*. Design and analysis of quorum sensing language “Interpreter” ecosystem for microbial community, Chemical Engineering Journal. 2024; 153148.
6. Niu T.; Yan X.; Wang J.; Song H.; Cui Y.; Cai X.; Chang K. A.; Qiao J. #; Wen M. #; He J. # Engineering of Pichia pastoris for the de novo synthesis of the sesquiterpene zealexin A1 from methanol. ACS Sustainable Chem. Eng. 2024, 12, 34, 12786-12794.
7. Zhang H, Chen D, Zhang P, Qiao J*, et al.Mining and validating quorum sensing interference molecules from food-derived compounds for Salmonella Typhimurium. Food & function 2025, 16,10 3918-3933.
8. Zhang, Y, Sun W, Wu H, Qiao J* et al. Receptor-targeted Lactococcus lactis mitigate Clostridioides difficile infection. Microbiological research, 2025, 299, 128221.
9. Wu H, Zhang Y, Zhao Z, Qiao J* et al. sRNA C263 activated by transcriptional regulator RmaE modulates the cell wall under acid stress. Journal of dairy science, 2025, S0022-0302(25)00385-6. 28.
10. Wu S, Bu X, Chen D, Wu X, Wu H*, Caiyin Q*, Qiao J*. Molecules-mediated bidirectional interactions between microbes and human cells. NPJ Biofilms Microbiomes. 2025, 11, 38.
11. Yuan L, Wu S, Wu H, Qiao J*, et al. Nisin-relevant antimicrobial peptides: synthesis strategies and applications. Food & function 2024, 15,19 9662-9677.
12. Nie, S.; Wang, S.; Chen, R.; Ge, M.; Yan, X.#; Qiao, J.# Catalytic Mechanism and Heterologous Biosynthesis Application of Sesquiterpene Synthases. J. Agric. Food Chem. 2024, 72 (13), 6871-6888.
13. Chen, R., Wang, J., Xu, J., Nie, S., Chen, C., Li, Y., Li, Y., He, J., Li, W.#, Wen, M.#, Qiao, J#. Heterologous Biosynthesis of Kauralexin A1 in Saccharomyces cerevisiae through Metabolic and Enzyme Engineering. J Agric Food Chem. 2024, 72 (13), 7308-7317.
14. Wu S, Zhou H, Chen D, Lu Y, Li Y, Qiao J.# Multi-omic analysis tools for microbial metabolites prediction. Brief Bioinform. 2024 May 23;25(4):bbae264.
15. Wu S, Qu Z, Chen D, Wu H, Caiyin Q, Qiao J.# Deciphering and designing microbial communities by genome-scale metabolic modelling. Comput Struct Biotechnol J. 2024 Apr 22;23:1990-2000.
16. Wu S, Zhou Y, Dai L*, Yang A*, Qiao J*. Assembling functional microbial ecosystems from molecular circuits to communities. FEMS Microbiology Reviews. 2024, fuae026.
17. Chen D, Qu Z, Yang S, Wu S*, Qiao J*. Quorum sensing regulating the productivity and stability of cross-feeding cocultivation. Chemical Engineering Journal. 2024, 502, 158167.
18. Wang, S.; Zhan, C.; Nie, S.; Tian, D.; Lu, J.; Wen, M.; Qiao, J.; Zhu, H.; Caiyin, Q. Enzyme and Metabolic Engineering Strategies for Biosynthesis of alpha-Farnesene in Saccharomyces cerevisiae. J. Agric. Food Chem. 2023, 71 (33), 12452-12461.
19. Wang, S.; Chen, R.; Yuan, L.; Zhang, C.; Liang, D.; Qiao, J.# Molecular and Functional Analyses of Characterized Sesquiterpene Synthases in Mushroom-Forming Fungi. J Fungi (Basel). 2023, 9 (10), 1017.
20. Yan, X., Li, Y., Li, W., Liang, D., Nie, S., Chen, R., Qiao, J., Wen, M.#, Caiyin, Q.#. Transcriptome Analysis and Identification of Sesquiterpene Synthases in Liverwort Jungermannia exsertifolia. Bioengineering (Basel). 2023, 10 (5), 569.
21. Wu S, Yang S, Wang M, Song N, Feng J, Wu H, Yang A, Liu C, Li Y, Guo F, Qiao J.# Quorum sensing-based interactions among drugs, microbes, and diseases. Sci China Life Sci. 2023, 66(1):137-151.
22. Zheng Y, Du Y, Qiu Z, Liu Z, Qiao J#, Li Y, Caiyin Q. Nisin Variants Generated by Protein Engineering and Their Properties. Bioengineering (Basel). 2022, 9(6):251.
23. Du Y, Li L, Zheng Y, Liu J, Gong J, Qiu Z, Li Y, Qiao J#, Huo YX. Incorporation of Non-Canonical Amino Acids into Antimicrobial Peptides: Advances, Challenges, and Perspectives. Appl Environ Microbiol. 2022, 88(23):e0161722.
24. Tian K, Hong X, Guo M, Li Y, Wu H, Caiyin Q, Qiao J#. Development of Base Editors for Simultaneously Editing Multiple Loci in Lactococcus lactis. ACS Synth Biol. 2022, 11(11):3644-3656.
25. Feng J, Wu S, Yang H, Ai C, Qiao J, Xu J, Guo F. Microbe-bridged disease-metabolite associations identification by heterogeneous graph fusion. Brief Bioinform. 2022, 23(6):bbac423.
26. Wu H, Zhang Y, Li L, Li Y, Yuan L, E Y, Qiao J. Positive regulation of the DLT operon by TCSR7 enhances acid tolerance of Lactococcus lactis F44. J Dairy Sci. 2022, 105(10):7940-7950.
27. Du Y, Song W, Yin Z, Wu S, Liu J, Wang N, Jin H, Qiao J, Huo YX. Genomic Analysis Based on Chromosome-Level Genome Assembly Reveals an Expansion of Terpene Biosynthesis of Azadirachta indica. Front Plant Sci. 2022, 13:853861.
28. Song Q, Wu H, Zhang P, Tian K, Zhu H, Qiao J. LssR plays a positive regulatory role in acid and nisin tolerance response of Lactococcus lactis. J Dairy Sci. 2022, 105(8):6483-6498.
29. Wu H, Tian K, Feng J, Qi H, Qiao J*. Systems-Level Analysis of the Global Regulatory Mechanism of CodY in Lactococcus lactis Metabolism and Nisin Immunity Modulation. Appl Environ Microbiol. 2022, 88(5):e0184721.
30. Wu S, Qiao, J*, Yang A, Liu C, Potential of orthogonal and cross-talk quorum sensing for dynamic regulation in cocultivation. Chem. Eng. J. 2022, 445.
31. Tian, K., Hong, X., Guo, M., Li, Y., Wu, H., Caiyin, Q.,# and Qiao J#. Development of Base Editors for Simultaneously Editing Multiple Loci in Lactococcus lactis.ACS Synth. Biol. 2022, 11(11), 3644–3656.
32. Wang, S., Zhan, C., Chen, R., Li, W., Song, H., Zhao, G., Wen, M., Liang, D.#, Qiao, J#. Achievements and perspectives of synthetic biology in botanical insecticides. J Cell Physiol. 2022, 1–16.
33. Li, W., Yan, X., Zhang, Y., Liang, D., Caiyin, Q., Qiao, J#. Characterization of trans-Nerolidol Synthase from Celastrus angulatus Maxim and Production of trans-Nerolidol in Engineered Saccharomyces cerevisiae. J Agric Food Chem. 2021, 69 (7), 2236-2244.
34. Liang, D., Li, W., Yan, X., Caiyin, Q., Zhao, G., Qiao, J#. Molecular and Functional Evolution of the Spermatophyte Sesquiterpene Synthases. Int J Mol Sci. 2021, 22 (12), 6348.
35. Yan, X., Li, W., Liang, D., Caiyin, Q., Zhao, G., Zhang, Z., Wen, M., Qiao, J#. De novo assembly of the Mylia taylorii transcriptome and identification of sesquiterpene synthases. Arch Biochem Biophys. 2021, 698, 108742.
36. Yan, X., Li, W., Liang, D., Zhao, G., Caiyin, Q.#, Qiao, J#. Comparative transcriptome analysis of sesquiterpene biosynthesis and functional characterization of sesquiterpene synthases in Leonurus sibiricus L. Planta. 2021, 253 (3), 71.
37. Lu J, Wu T, Zhang B, Liu S, Song W, Qiao J#, Ruan H. Types of nuclear localization signals and mechanisms of protein import into the nucleus. Cell Commun Signal. 2021,19(1):60.
38. Liu J, Huang R, Song Q, Xiong H, Ma J, Xia R, Qiao J#. Combinational Antibacterial Activity of Nisin and 3-Phenyllactic Acid and Their Co-production by Engineered Lactococcus lactis. Front Bioeng Biotechnol. 2021, 5;9:612105.
39. Wu S, Xue Y, Yang S, Xu C, Liu C, Liu X, Liu J, Zhu H, Zhao GR, Yang A, Qiao J#. Combinational quorum sensing devices for dynamic control in cross-feeding cocultivation. Metab Eng. 2021, 67:186-197.
40. Wu S, Liu C, Feng J, Yang A, Guo F, Qiao J. QSIdb: quorum sensing interference molecules. Brief Bioinform. 2021, 22(4):bbaa218.
41. Wu S, Xu C, Liu J, Liu C, Qiao J#. Vertical and horizontal quorum-sensing-based multicellular communications. Trends Microbiol. 2021, 29(12):1130-1142.
42. Yuan L, Wu H, Wang B, Jia C, Liang D, Caiyin QG, Qiao J. ComX improves acid tolerance by regulating the expression of late competence proteins in Lactococcus lactis F44. J Dairy Sci. 2021 Sep;104(9):9556-9569.
43. Li, W1.; Yan X.1; Zhang, Y.; Liang, D.; Caiyin, Q.; Qiao, J.# Characterization of trans-Nerolidol Synthase from Celastrus angulatus Maxim and Production of trans-Nerolidol in Engineered Saccharomyces cerevisiae. J Agric Food Chem 2021, 69 (7), 2236-2244.
44. Yan, X.; Li, W.; Liang, D.; Caiyin, Q.; Zhao, G.; Zhang, Z.; Wen, M.; Qiao, J.# De novo assembly of the Mylia taylorii transcriptome and identification of sesquiterpene synthases. Arch. Biochem. Biophys. 2021, 698, 108742.
45. Yan, X.; Li, W.; Liang, D.; Zhao, G.; Caiyin, Q.; Qiao, J.# Comparative transcriptome analysis of sesquiterpene biosynthesis and functional characterization of sesquiterpene synthases in Leonurus sibiricus L. Planta 2021, 253 (3), 71.
46. Wu S, Liu J, Liu C, Yang A, Qiao J#. Quorum sensing for population-level control of bacteria and potential therapeutic applications. Cell Mol Life Sci. 2020, 77(7):1319-1343.
47. Wu H, Xue E, Zhi N, Song Q, Tian K, Caiyin Q, Yuan L, Qiao J#. d-Methionine and d-Phenylalanine Improve Lactococcus lactis F44 Acid Resistance and Nisin Yield by Governing Cell Wall Remodeling. Appl Environ Microbiol. 2020, 86(9):e02981-19.
专利成果：
1. 乔建军,闫晓光,付梦娣,等.一种高产檀香醇的酿酒酵母工程菌株及构建方法与应用[P].浙江省:CN202410434345.1,2024-07-02.
2. 乔建军, 闫晓光, 阮潮峰, 等.一种檀香烯合成酶突变体以及应用[P].浙江省:CN202311717827.X,2024-03-15.
3. 乔建军,李伟国,周洪龙等.法尼烯合成酶突变体、基因、基因工程菌及其应用[P].浙江省:CN202311610081.2,2024-03-15.
4. 乔建军,王胜利,田炎杰等.法尼烯合成酶突变体及编码基因[P].浙江省:CN202311671548.4,2024-03-15.
5. 乔建军,李伟国,秦臻等.4-羟基苯乙酸-3-羟化酶突变体及其应用[P].浙江省:CN202410280847.3,2024-08-02.
6. 乔建军,吴昊,易德伟,寇佳祥,刘柯,钱永清,刘江波.一种AKK菌的选择培养基及其应用[P].浙江省: CN202311739204.2,2024-04-05.
7. 乔建军,吴昊,刘柯,易德伟,王晓娜,牛宇琴,钱永清,刘江波.一种卷曲乳杆菌的食品级培养基及其应用[P].浙江省: CN202311731325.2,2024-04-16.
8. 刘江波,乔建军,吴昊,王卉,易德伟,刘柯,钱永清.一种唾液乳杆菌微胶囊的制备方法[P].浙江省: CN202311719426.8,2024-04-19.
9. 吴昊,乔建军,熊慧,财音青格乐,韩欢,钱永清,赵秀丽.一种植物乳杆菌及在制备抗氧化药物或化妆品中的应用[P].浙江省: CN202311498773.2,2024-03-01.
10. 乔建军,李伟国,杨丹等.橙花叔醇在制备植物防冻剂中的应用[P].浙江省:CN202310124204.5,2024-08-16.
11. 乔建军,吴昊,易德伟,刘柯,寇佳祥.一种乳酸菌复合冻干保护剂及其应用[P].浙江省:CN202311460085.7,2024-02-02.
12. 田开仁,洪霞,乔建军,等. 无痕基因整合的乳酸乳球菌及构建方法[P].浙江省：202411041093.2,2024-07-31.
13. 乔建军,吴昊,刘金贵,熊慧,赵秀丽.乳酸乳球菌乳亚种YF11转录调控因子YthA[P].浙江省: CN202211198239.5,2023-05-05.
14. 韩欢,乔建军,徐玮,吴昊,钱永清.一种DHA藻油燕窝酸口溶膜剂及其制备方法[P].浙江省: CN202310121532.X,2023-06-27.
15. 乔建军,王凯,张恩鹏 ,等. 一种生产 L-乳酸的基因工程菌株及构建方法 [P].浙江省：202311664679.X,2023-12-06.
16. 乔建军,张恩鹏,王凯 ,等. 一种生产三乙酸内酯的基因工程菌株及构建方法 [P].浙江省：202311664675.1 ,2023-12-06.
17. 乔建军,杨海霞,王凯 ,等. 一种生产比卡菌素的基因工程菌株及构建方法 [P].浙江省：202311664682.1 ,2023-12-06.
18. 乔建军,田开仁,周丹丹,等. 一种乳酸乳球菌多基因高效迭代整合的方法[P].浙江省：202310140909.6,2023-02-21.
19. 乔建军,王胜利,田炎杰,李伟国,梁冬梅,刘大苗.法尼烯合成酶突变体及编码基因[P]. 浙江省:CN117701545A,2023-12-07
20. 李伟国,乔建军,汤敏,王胜利,刘大苗,梁冬梅.一种法尼烯合成酶突变体和编码基因及应用[P]. 浙江省:CN117660426A,2023-11-16
21. 乔建军,闫晓光,聂升鑫,等.一种双环吉玛烯合成酶突变体和基因序列以及应用[P].浙江省:CN202211475718.7,2023-04-11.
22. 闫晓光,乔建军,卢亚莉,等.白千层醇合成酶Agr5突变体及其编码基因与应用[P].浙江省:CN202310860456.4,2023-12-08.
23. 乔建军,李伟国,宋洪健等.橙花叔醇合成酶突变体、基因、基因工程菌及其应用[P].浙江省:CN202310236123.4,2023-07-14.
24. 闫晓光,乔建军,卢亚莉等.白千层醇合成酶 Agr5 突变体及其编码基因与应用[P].浙江省:CN202310860456.4,2023-12-08.
25. 乔建军,熊慧,吴昊,刘家亨,徐程杨.高产乳酸链球菌素的乳酸乳球菌重组菌株及其构建方法和应用[P].浙江省: CN202211264864.5,2023-04-07.
26. 乔建军,吴昊,訾灿,赵秀丽.一种粪便采集器[P].浙江省: CN202222707557.1,2022-10-14.
27. 乔建军,吴昊,訾灿,赵秀丽.真空式粪便取样器[P].浙江省: CN202222717897.2,2022-10-14.
28. 乔建军,吴昊,訾灿,赵秀丽.一种推进式粪便取样器[P].浙江省: CN202222707902.1, 2022-10-14.
29. 乔建军,寇佳祥,吴昊,朱宏吉,张悦.一种粪菌冷冻保护剂及其在粪菌保藏中的应用[P].浙江省: CN202111412800.0,2022-03-18.
30. 乔建军,张悦,赵兴旺,财音青格乐,刘家亨,吴昊.一种贝莱斯芽孢杆菌及发酵方法与应用[P].中国: ZL202011000604.8,2022-08-12.
31. 乔建军,薛二淑,吴昊,财音青格乐,宋倩倩,田开仁,支宁.一种重组乳酸乳球菌菌株及其方法和应用[P].中国: ZL201910091383.0,2022-07-08.
32. 乔建军，易德伟，张恩鹏，等.一种聚酮合酶基因及编码的聚酮合酶与应用[P].浙江省：202211645025.8,2022-12-21
33. 乔建军,王凯, 杨海霞, 等.从Kabatiella bupleuri 发酵液中提取蔥醌类化合物的方法[P].浙江省：202211645028.1,2022-12-21.
34. 乔建军, 徐俊松, 王凯,等.Kabatiella bupleuri菌株内源U6启动子及基因编辑载体[P].浙江省：202211645029.6,2022-12-21.
35. 乔建军,王凯,张恩鹏 ,等.一种漆酶及其编码基因[P].浙江省：202211645030.9,2022-12-21.
36. 乔建军,张恩鹏,王凯 ,等.利用Kabatiella bupleuri 菌株发酵生产蔥醌类化合物的发酵培养基[P].浙江省：202211645031.3,2022-12-21.
37. 乔建军,杨海霞,王凯 ,等. Kabatiella bupleuri 发酵液中蔥醌类化合物的检测方法[P].浙江省：202211645033.2,2022-12-21.
38. 乔建军,王凯,张恩鹏 ,等.一种多环芳烃羟化酶基因及编码的多环芳烃羟化酶[P].浙江省：202211645034.7,2022-12-21.
39. 乔建军,王凯,张恩鹏 ,等.一 种 产 蔥 醌 类 化 合 物 的 K a b a t i e l l a b u p l e u r i 菌 株 及 应 用[P].浙江省：202211645047. 4,2022-12-21.
40. 乔建军,刘家亨,吴昊,吴小芳,财音青格乐.高产乳酸链球菌素的重组乳酸乳球菌及构建方法[P].中国: ZL201811439305.7,2021-11-23.
41. 乔建军,李晨辰,宋倩倩,财音青格乐,吴昊.一种nisin热敏脂质体及其制备方法和应用[P].中国: ZL201810387040.4,2021-06-08.
42. 乔建军,赵秀丽,吴昊,刘家亨,财音青格乐,朱宏吉.一种控制发酵培养体系pH值以提高乳酸链球菌素产量的方法[P].中国: ZL201611131569.7,2020-09-15.
43. 乔建军,赵秀丽,周丹丹,吴昊,财音青格乐,李艳妮,朱宏吉. 乳酸乳球菌乳亚种YF11的非编码小RNA s013及应用[P].中国: ZL201611071306.1,2020-09-15.
