个人简介

天津大学英才教授，博士生导师。海外高层次人才， 国家特聘专家。1989年硕士毕业于天津大学化工学院精细化工专业，1994年博士毕业于名古屋大学工学部应用化学及合成化学专业，1994年加入日本帝人制药从事新药研发，1999-2000年于斯坦福大学化学系从事博士后研究，2001-2009于美国硅谷生物医药公司从事新药研发，2009年加入天津大学。

学术兼职

系统生物工程教育部重点实验室 副主任

研究领域

① 活性天然产物的生物与化学合成及靶向药物研发；② 功能分子的理性设计与靶向传递；③ 药物分子活性构象精准预测智能算法开发与应用

学术成就

在中枢神经领域完成靶向创新药物IND 4项；以第一发明人设计研发脑卒中靶向治疗创新药完成NDA 1项；主持国家重点研发计划课题 2项；在生物医药等领域申报及获权发明专利 70余项；在 J. Med. Chem.、Eur. J. Med. Chem.、J. Agric. Food Chem.、Anal. Chem.、J. Chem. Inf. Model.、Adv. Sci.等发表论文 90余篇。

代表论文

(1) Manwei Jia, Xiangqian Gao, Jianbin Han, Ru Zhang, Yang Liu, Xiaoling Zhu, Chang Zheng, Jun Xu, Qingzhi Gao*, Shengnan Liu*, Designer Podophyllotoxin Derivatives with Significantly Improved Safety by Targeting LAT1 for the Treatment of Esophageal Cancer. J Med Chem. 2026, 69, 8, 9314–9333.

(2) Ziru Sun,# Jianbin Han,# Jun Xu, Weijie Song, Yujun Cui, Yang Liu, Liu Yang, Xiaoqi Meng, Jie Huang, Qingzhi Gao*, and Shengnan Liu*. Discovery of the Next-Generation Platinum-Based Anticancer Agents for Combating Oxaliplatin-Induced Drug Resistance. J Med Chem. 2024, 67, 10190-10210.

(3) Zhaoyong Kang, Yujie Yan, Ruirui Lu, Xiaoqi Dong, Jun Xu, Dong Zheng, Suhua Li* Qingzhi Gao* and Shengnan Liu*. Synthesis and Biological Profiling of Novel Strigolactone Derivatives for Arabidopsis Growth and Development. J Agric Food Chem. 2023, 71, 12859-12874.

(4) 董小绮，康兆勇，刘胜男*，高清志* 新型植物源天然产物杀虫剂研究进展. 农药学学报 2023, 25, 969-989.

(5) Shengnan Liu, Ziru Sun, Min Liang, Weijie Song, Ru Zhang, Yunli Shi, Yujun Cui*, Qingzhi Gao* An unrevealed molecular function of corannulene buckybowl glycoconjugates in selective tumor annihilation by targeting the cancer-specific Warburg effect. Advanced Science, 2022, 9, 21053.

(6) Shunjie Zhang, Xinyu Wang, Ru Zhang, Yujun Cui, Heming Zhang, Weijie Song, Xiaohan Hou, Shibo Fu, Qingzhi Gao*, Shengnan Liu*. A GLUT1 inhibitor-based fluorogenic probe for Warburg effect-targeted drug screening and diagnostic imaging of hyperglycolytic Cancers. Analytica Chimica Acta, 2021, 1167, 338593.

(7) Yang Li, Shengnan Liu,  Min Liang,  Yujun Cui, Hongxia Zhao * and Qingzhi Gao*. Glycocalixarene with luminescence for Warburg effect-mediated tumor imaging and targeted drug delivery. Chem. Commun., 2021, 57, 9728.

(8) Shengnan Liu *, Weijie Song,  Yujun Cui,  Ziru Sun,  Zhenhua Huanga and Qingzhi Gao*. A GLUT1 inhibitor-based probe significantly ameliorates the sensitivity of tumor detection and diagnostic imaging. Chem. Commun., 2021, 57, 5530.

(9) Yaru Li, ZiruSun, Yujun Cui, Heming Zhang, Shunjie Zhang, Xinyu Wang, Shengnan Liu*, Qingzhi Gao*. Oxaliplatin derived monofunctional triazole-containing platinum(II) complex counteracts oxaliplatin-induced drug resistance in colorectal cancer. Bioorganic Chemistry, 2021, 107, 104636.