康广博 副研究员 guangbo_kang@tju.edu.cn 生物医药工程、合成生物学
个人简介： 天津大学合成生物与生物制造学院、合成生物技术全国重点实验室副研究员，硕士生导师。国家现代中药创新中心技术专委会技术特派员，天津市生物与制药工程重点实验室秘书、中国医药教育协会代谢药学专业委员会青年委员、微生物学通报青年编委，天津大学科技领军创新人才培育“启明计划”项目负责人。招生方向：生物工程；生物化学与分子生物学；合成生物学；生物与医药。
研究领域：长期聚焦抗体药物和活菌生物药的理性设计、工艺开发和作用机制研究工作。
学术成就：曾获欧洲克罗恩病与结肠炎组织（ECCO）2024 Y-ECCO Congress Abstract Award，主持国家重点研发计划子课题2项，承担国家及省部级项目任务10余项。在Advanced Science、Gut Microbes、Biotechnology Advances和Science China Life Sciences等SCI期刊发表论文30余篇，获得中国发明专利授权10余项。
代表性文章：
1.Guangbo Kang†, Biao Zhang†, Jiahao Wu, Lina Wang, He Huang*. Engineering Probiotics as Living Biotherapeutics: A Novel Paradigm of Restoring Physiological Barriers via Targeted Short-Chain Fatty Acid Delivery[J]. SCIENCE CHINA Life Sciences, 2025.
2.Xiaobing Du†, Guangbo Kang†, Lina Wang, Zhichao Gong, Xu Jiang, Jiachen Pan, Xiaoying Li, Danping Zhang, He Huang,* Shuxian Meng*. Bacterial Armory: Engineering Dual-Photosensitized Bacteria for a TripleModal Therapy on Tumors[J]. Small, 2025.
3.Xinyu Hu†, Ling Jiang†, Haibin Yuan†, Wanyi Chen, Yufei Guo, Mengxue Gao, Yijia Song, Zichen Wang, Yuli Wang, Miao Zhang, Ario de Marco, He Huang*, Guangbo Kang*, Haoran Yu*. Noncanonical amino acid-aided synthesis of anti-PD-L1 bispecific nanobody for colon cancer immunotherapy[J]. Communications Biology, 2025.
4.Yufei Guo†, Mengxue Gao†, Lina Wang, Haibin Yuan, Jianan Yin, Jiahao Wu, Xinran Gao, Zhixin Zhu, Yan Zhang, Zichen Wang, He Huang*, Guangbo Kang*. An Engineered Probiotic Consortium Based on Quorum-Sensing for Colorectal Cancer Immunotherapy[J]. Advanced Science, 2025.
5.Zhichao Gong†, Guangbo Kang†, Yu Cao, Jiachen Pan, Xuejiao Rong, Xiaobing Du, Danping Zhang, He Huang*, Shuxian Meng*. Flexible Regulation of Optical Properties Based on Structure Size-Driven Intermolecular Interactions for Phototherapy[J]. Advanced Science, 2025.
6.Guangbo Kang†, Xiaoli Wang†, Mengxue Gao†, Lina Wang, Zelin Feng, Shuxian Meng, Jiahao Wu, Zhixin Zhu, Xinran Gao, Xiaocang Cao*, He Huang*. Propionate-producing engineered probiotics ameliorated murine ulcerative colitis by restoring anti-inflammatory macrophage via the GPR43/HDAC1/IL-10 axis[J]. Bioengineering & Translational Medicine,2024, e10682.
7.Jiahao Wu†, He Huang†, Lina Wang, Mengxue Gao, Shuxian Meng, Shaolan Zou, Yuanhang Feng, Zeling Feng, Zhixin Zhu, Xiaocang Cao*, Bingzhi Li*, and Guangbo Kang*. A tailored series of engineered yeasts for the cell-dependent treatment of inflammatory bowel disease by rational butyrate supplementation[J]. Gut Microbes, 2024, 16(1):2316575.
8.Xiuzhao Chen†, Mengxue Gao†, Lina Wang†, Guifen Qiang, Yili Wu, He Huang*, and Guangbo Kang*. A synthetic microbial consortium protects against obesity by regulating vitamin B6 metabolism[J]. Gut Microbes, 2024, 16(1):2304901.
9.Jiaqi Li†, Guangbo Kang†, Jiewen Wang, Haibin Yuan, Yili Wu, Shuxian Meng, Ping Wang, Miao Zhang, Yuli Wang, Yuanhang Feng, He Huang*, Ario de Marco*. Affinity maturation of antibody fragments: A review encompassing the development from random approaches to computational rational optimization[J]. International Journal of Biological Macromolecules, 2023, 247: 125733.
10.Zhuoce Dang†, Mengxue Gao†, Lina Wang, Jiahao Wu, Yufei Guo, Zhixin Zhu, He Huang*, Guangbo Kang*. Synthetic bacterial therapies for intestinal diseases based on quorum- sensing circuits[J]. Biotechnology Advances,2023,65:108142.
