1、个人简介
刘悦，副教授，本科毕业于天津大学生物工程专业，博士毕业于天津大学生物化工专业，2019年至2020年在哈佛大学医学院干细胞研究中心联合培养。
邮箱：yueliu@tju.edu.cn
研究方向:合成生物学使能技术、合成基因组学
2、研究领域
长期从事合成生物学研究，围绕复杂基因组设计、人工染色体构建及跨物种功能重塑等前沿方向开展工作。1）建立复杂基因组从头设计与组装技术体系，实现Mb级高重复序列基因组的精准构建；2）发展人工染色体跨物种递送技术，突破超大DNA分子完整转移的关键瓶颈；3）构建合成基因组表观重编程与功能重塑研究平台，揭示外源基因组在异源细胞中的适应与调控规律。
3、学术成就
主持国家重点研发“合成生物学”青年科学家项目、国家重点研发计划子课题、国家自然科学基金委青年基金（C类）、博士后特别资助等。相关研究成果以第一作者发表在Nature Methods、Nature Protocols、Energy & Environmental Science等高水平学术期刊。申请发明专利11项，授权8项。编写国家级教材《基因组设计与合成》和省部级教材《合成生物学》。担任Synthetic Biology and Engineering期刊青年编委。
4、代表性文章
1. Yue Liu#, Jianting Zhou#, Duo Liu, Xiaoyu Hu, Lin Yang, Xue-Ru Song, Xiao-Dong Jin, Wei Xie, Luhan Yang, Zichuan Liu, and Ying-Jin Yuan*. De novo assembly and delivery of synthetic megabase-scale human DNA into mouse early embryos. Nature Methods 22, 1686–1697 (2025).
2. Yue Liu, Jianting Zhou, Zichuan Liu, and Ying-Jin Yuan*. Yeast nuclei–mediated precise delivery of synthetic megabase-scale human DNA into mammalian embryos. Nature Protocols (2026). https://doi.org/10.1038/s41596-026-01374-6.
3. Yue Liu, Mingzhu Ding, Wei Ling, Yun Yang, Xiao Zhou, Bing-Zhi Li, Tao Chen, Yong Nie, Miaoxiao Wang, Boxuan Zeng, Xia Li, Hong Liu, Baode Sun, Heming Xu, Jiamei Zhang, Yi Jiao, Yanan Hou, Hui Yang, Sijia Xiao, Qucheng Lin, Xinzi He, Wenjie Liao, Zeqi Jin, Yufei Xie, Bofeng Zhang, Tianyu Li, Xi Lu, Jiabei Li, Fan Zhang, Xiao-Lei Wu, Hao Song*, and Ying-Jin Yuan*. A three-species microbial consortium for power generation. Energy & Environmental Science 10.7 (2017): 1600-1609.
4. Ying-Jin Yuan and Yue Liu. Delivering intact, naive, synthetic megabase-scale human DNA into mammalian embryos using SynNICE. Nature Methods 22.8 (2025): 1632-1633. (Research briefing)
5. Yue Liu, Ying-Jin Yuan*. The emerging dialogue between synthetic genomics and clinical research. Clinical and Translational Medicine (2026);16: e70738. (Invited letter)
6. Yi Wu#, Bing-Zhi Li#, …, Yue Liu, …, Ying-Jin Yuan*. Bug mapping and fitness testing of chemically synthesized chromosome X. Science 355.6329 (2017): eaaf4706.
7. Ze-Xiong Xie#, Bing-Zhi Li#, …, Yue Liu, …, Ying-Jin Yuan*. “Perfect” designer chromosome V and behavior of a ring derivative. Science 355.6329 (2017): eaaf4704.
8. Nikki R Kong, Mahmoud A Bassal, Hong Kee Tan, Jesse V Kurland, Kol Jia Yong, John J Young, Yang Yang, Fudong Li, Jonathan D Lee, Yue Liu, Chan-Shuo Wu, Alicia Stein, Hongbo R Luo, Leslie E Silberstein, Martha L Bulyk, Daniel G Tenen*, and Li Chai* Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression. Cell Reports 34.1 (2021).
9. Ming-Zhu Ding, Hao Song, En-Xu Wang, Yue Liu, and Ying-Jin Yuan*. Design and construction of synthetic microbial consortia in China. Synthetic and Systems Biotechnology 1.4 (2016): 230-235.
