个人简介
天津大学菁英教授，博士生导师，国家优青。硕博毕业于复旦大学。现任生物化工系师生联合党支部书记。入选天津市“131”人才工程、天津市青年科技工作者协会优秀青年科技工作者。获评天津大学优秀毕业论文指导教师、优秀班导师、优秀师友导师。
电子邮件：chi.yao@tju.edu.cn
研究方向:DNA纳米技术，生命分析化学，生物功能材料，合成生物学
研究领域
面向重大疾病精准诊断的需求，开展基于DNA纳米技术的活细胞识别与传感研究工作。1）构建了多聚功能核酸作为分子识别新工具，提高了低丰度靶标细胞分子识别的灵敏度；2）建立了核酸网络在活细胞界面分子识别和原位组装的新方法，提高了复杂体系中细胞识别的特异性；3）发展了核酸探针在活细胞内分子识别和响应的新技术，提高了活体中靶标细胞内动态分子信号识别与传感的稳定性。
学术成就
主持国家自然科学基金委优青、面上项目，以及国家重点研发计划、天津市自然基金项目等。发表SCI论文86篇，其中第一/通讯作者论文65篇，包括1篇PNAS、2篇Nat Protoc、1篇 Sci Adv、3篇JACS、4篇Angew Chem、1篇Nat Commun、4篇Adv Mater、3篇Anal Chem、1篇Chem Rev和2篇Acc Chem Res等。获授权中国发明专利8项，转化2项。获中国化工学会科学技术奖-基础研究成果奖二等奖。编写教材著作《合成基因组学》《核酸纳米技术》《核酸功能材料》。担任Extracellular Vesicle、Advanced Sensor and Energy Materials和Chinese Chemical Letters期刊青年编委。
代表性文章
1. Yanfei Guo+, Yan Huang+, Siqi Li, Dayong Yang*, Chi Yao*, Programmable DNA nanostructures for hTERT compartmentalization and translocation in living cells, Angewandte Chemie International Edition, 2026, DOI: 10.1002/anie.202525891.
2. Nachuan Song+, Hongjin Li+, Ruoyu Tao, Yan Huang, Rui Zhang, Jianfeng Guo*, Peifeng Liu*, Chi Yao*, Dayong Yang*, A smart DNA nanoframework enables synergistic photodynamic therapy of pancreatic cancer. Advanced Materials, 2025, DOI: 10.1002/adma.202416161.
3. Huaixin Zhao+*, Lijun Wang+, Sen Yang+, Zhuiyun Li+, Xiaocui Guo, Chen Zuo, Guoming Xie, Chi Yao*, Dayong Yang*, Smart energy-storing DNA hydrogel for on-demand laser-free photoimmunotherapy of melanoma. Journal of the American Chemical Society, 2025, DOI: 10.1021/jacs.5c06905.
4. Zhaoyue Lv, Peiran Li, Mingxing Liu, Chi Yao*, Dayong Yang*，Hybridization chain reaction-based DNA nanoframeworks for biosensing and therapeutic applications. Nature Protocols, 2025, DOI: 10.1038/s41596-025-01183-3.
5. Nachuan Song+, Ruoyu Tao+, Hongjin Li, Rui Zhang, Yan Huang, Le Zhang, Ying Liu*, Dayong Yang*, Chi Yao*, Spatially controlled co-delivery of diagnostic and therapeutic agents using DNA nanoframeworks for pancreatic cancer precision therapy. Angewandte Chemie International Edition, 2025, DOI: 10.1002/anie.202500566.
6. Sen Yang+, Junlin Wu+, Zhongyu Wang, Yu Cheng, Rui Zhang, Chi Yao*, Dayong Yang*, A smart DNA hydrogel enables synergistic immunotherapy and photodynamic therapy of melanoma. Angewandte Chemie International Edition, 2024, 136, e202319073.
7. Nachuan Song+, Hongjin Li+, Chi Yao*, Dayong Yang*, Dynamic chemistry of DNA-Based Nanoassemblies in Living Cells. Accounts of Chemical Research, 2024, 57, 2763.
8. Nachuan Song+, Xiaoting Fan+, Xiaocui Guo+, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Chi Yao*, Peifeng Liu*, A DNA/upconversion nanoparticle complex enables controlled co-delivery of CRISPR-Cas9 and photodynamic agents for synergistic cancer therapy. Advanced Materials, 2024, 36, 2309534.
9. Jianpu Tang+, Xuemei Jia+, Qian Li+, Zhen Cui, Aiqi Liang, Bin Ke, Dayong Yang*, Chi Yao*, A DNA-based hydrogel for exosome separation and biomedical applications. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, e2303822120.
10. Nachuan Song+, Yiwen Chu+, Shuai Li, Yuhang Dong, Xiaoting Fan, Jianpu Tang, Yanfei Guo, Guangshuai Teng, Chi Yao*, Dayong Yang*, Cascade dynamic assembly/disassembly of DNA nanoframework enabling the controlled delivery of CRISPR-Cas9 system. Science Advances, 2023, 9, eadi3602.
11. Yanfei Guo, Siqi Li, Zhaobin Tong, Jianpu Tang, Rui Zhang, Zhaoyue Lv, Nachuan Song, Dayong Yang*, Chi Yao*, Telomerase-mediated self-assembly of DNA network in cancer cells enabling mitochondrial interference. Journal of the American Chemical Society, 2023, 145, 23859.
12. Zhaoyue Lv+, Mengxue Huang+, Jing Yang+, Peiran Li, Lele Chang, Qianyun Tang, Xiaojing Chen, Shengqi Wang*, Chi Yao*, Peifeng Liu*, Dayong Yang*, A smart DNA-based nanosystem containing ribosome-regulating siRNA for enhanced mRNA transfection. Advanced Materials, 2023, 2300823.
13. Chi Yao+*, Yuwei Xu+, Jianpu Tang+, Pin Hu, Hedong Qi, Dayong Yang*, Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome. Nature Communications, 2022, 13, 7739.
14. Chi Yao+, Hedong Qi+, Xuemei Jia, Yuwei Xu, Zhaobin Tong, Zi Gu, Dayong Yang*, A DNA nanocomplex containing cascade DNAzymes and promoter-like Zn-Mn-Ferrite for combined gene/chemo-dynamic therapy. Angewandte Chemie International Edition, 2022, 61, e202113619.
15. Chi Yao+, Junhan Ou+, Jianpu Tang+, Dayong Yang*, DNA supramolecular assembly on micro/nanointerfaces for bioanalysis. Accounts of Chemical Research, 2022, 15, 2043.
16. Chi Yao+, Rui Zhang+, Jianpu Tang, Dayong Yang*, Rolling circle amplification (RCA)-based DNA hydrogel. Nature Protocols, 2021, 16, 5460.
17. Chi Yao+, Chenxu Zhu+, Jianpu Tang, Junhan Ou, Rui Zhang, Dayong Yang*, T lymphocyte-captured DNA network for localized immunotherapy. Journal of the American Chemical Society, 2021, 143, 19330.
18. Chi Yao+, Han Tang+, Weijian Wu, Jianpu Tang, Weiwei Guo, Dan Luo, Dayong Yang*, Double rolling circle amplification generates physically crosslinked DNA network for stem cell fishing. Journal of the American Chemical Society, 2020, 142, 3422.
