1、个人简介
王颖 英才副教授/博导
邮箱：ying.wang@tju.edu.cn
研究方向；合成生物学/生物制造/萜烯类细胞工厂的精准构建与精细调控
天津大学合成生物与生物制造学院英才副教授，博士研究生导师；《合成生物学》期刊编委会委员，天津市生物医学工程学会医学生物技术专委会委员；主讲本研贯通-产教融合-合成生物学专业核心课程“人工细胞工厂设计构建”。
2005年在南开大学获得学士学位，2012年在中科院上海植物生理生态研究所微生物专业获得博士学位，2012-2014年在复旦大学生命科学院从事博士后研究工作，2014 年 11 月起至今在天津大学任教。
2、研究领域
瞄准萜烯类和甾体类天然产物高效生产菌株的设计构建和测试放大，聚焦目标产品细胞毒性高、菌株代谢流控制难等瓶颈问题，开展底盘细胞物质流、能量流时空动态调控关键技术研究。具体包括：
（1）底盘调控靶点的挖掘与数字细胞的构建应用；
（2）代谢途径空间调控机制的解析与重构；
（3）细胞微观调控与发酵宏观控制耦合机制的探索与适配；
3、学术成就（包括但不限于）
先后承担千万级重大攻关任务以及国家重点研发计划课题、国家自然科学基金等国家级项目11项；在 Green Chemistry、Journal of Agricultural and Food Chemistry等一区top期刊、Synthetic and Systems Biotechnology等国内SCI期刊以及ACS Synthetic Biology等高水平SCI期刊上发表论文 48 篇；获得中国发明专利授权 33 项，多项生物合成成果已转化应用；指导学生完成市级大学生创新创业训练项目；作为副主编出版国家“十四五”新兴领域教材《人工细胞工厂设计构建》。
4、代表性文章
(1) Tianyu Dong, Xiao Zhou, Zheng-Jie Hou, Yujie Shu, Mingdong Yao, Zhi-Hua Liu, Jing-Sheng Cheng, Wenhai Xiao*,Ying Wang*. Multiple strategies enhance 7-dehydrocholesterol production from kitchen waste by engineered Yarrowia lipolytica. Journal of Agricultural and Food Chemistry. 2025, 73 (1):693-705.
(2) Qi Gao, Herong Wang, Mengying Shan, Fangyuan Wu, Guozhen Jiang, Mingdong Yao, Ying Wang*, Wenhai Xiao*, Ying-Jin Yuan Systematic engineering to enhance citronellol production in yeast. Journal of Agricultural and Food Chemistry. 2025, 73 (24):15189-15198.
(3) Ying Wang, Ruosi Zhang, Mingdong Yao, Wenhai Xiao*, Ying Wang*, Ying-Jin Yuan. Transcriptomic studies on the product stress response revealed that YCF1 is a beneficial factor for progesterone production in Yarrowia lipolytica. Synthetic and Systems Biotechnology. 2025, 10(4):1087-1097.
(4) Nan Wu, Mingdong Yao, Wenhai Xiao, Ying Wang*, Ying-Jin Yuan. Highly efficient synthesis of lysergic acid using engineered budding yeast. Green Chemistry 2024,26(19):10330-10343.
(5) Nan Wu, Mingdong Yao, Wenhai Xiao, Tianyu Dong, Haidi Ma, Xianli Du*, Ying Wang*, Yingjin Yuan. Modular Pathway Compartmentalization for Agroclavine Overproduction in Saccharomyces cerevisiae: ACS Synthetic Biology. 2023,12(4): 1133-1145.
(6) Ruosi Zhang, Mingdong Yao, Haidi Ma, Wenhai Xiao, Ying Wang*, Yingjin Yuan. Modular coculture to reduce substrate competition and off-target intermediates in androstenedione biosynthesis: ACS Synthetic Biology. 2023, 12(3):788-799.
(7) Xiaojing Guo, Mingdong Yao, Wenhai Xiao, Ying Wang*, Guangrong Zhao, Yingjin Yuan. Compartmentalized reconstitution of post-squalene pathway for 7-dehydrocholesterol overproduction in Saccharomyces cerevisiae. Frontiers in Microbiology, 2021, 12:663973.
(8) Boxuan Zeng, Mingdong Yao, Wenhai Xiao, Yunzi Luo, Ying Wang*, Yingjin Yuan. Endogenous 2μ plasmid editing for pathway engineering in Saccharomyces cerevisiae. Frontiers in Microbiology, 2021, 12:631462.
