个人简介

姚明东

mingdong.yao@tju.edu.cn

研究方向:合成生物学，细胞工厂，酶工程

天津大学合成生物与生物制造学院副研究员，博士生导师，合成生物学系副系主任。天津大学化工学院应用化学专业本科，日本东京大学应用生命化学专业硕士和博士，中科院大连化学物理研究所博士后.

https://tj.teacher.360eol.com/teacherBasic/preview?teacherId=3113

研究领域

主要开展萜烯类天然产物生物合成方面的研究工作，在萜类天然产物细胞工厂构建分析，合成路径适配再造、关键酶元件的构效解析和设计优化等科研领域积累了丰富的研究成果和研究经验，致力于提升高价值产物的生物合成效率。

研究方向是酶的设计优化及其在细胞工厂中的适配性应用，主攻萜烯类天然产物合成酶的研究和应用，具体涉及（1）细胞工厂的设计构建；（2）酶的构效关系研究和优化；（3）酶与底盘的适配优化和应用。

学术成就（包括但不限于）

在 Proceedings of the National Academy of Sciences of the United States of America、Metabolic Engineering、Journal of Hazardous Materials、ACS Sustainable Chemistry & Engineering等国际知名刊物发表 SCI 论文 50 余篇；主持国家和省部级科研项目及课题5 项；授权发明专利 10 余项。

代表性文章

1. He Hao #, Mingdong Yao #, Ying Wang, Chenglong Zhang, Zihe Liu, Jens Nielsen, Shuobo Shi, Wenhai Xiao, Yingjin Yuan. Extending the G1 phase improves the production of lipophilic compounds in yeast by boosting enzyme expression and increasing cell size. Proceedings of the National Academy of Sciences of the United States of America. 2024, 121(47): e2413486121.

2. Chenglong Zhang, Jia Wang, Yi Shi, Nan Wu, Xia Li, Ying Wang, Bingzhi Li, Wenhai Xiao*, Mingdong Yao*, Yingjin Yuan. Improving the expression of taxadiene synthase to enhance the titer of taxadiene in Saccharomyces cerevisiae. Green Chemistry. 2024, 26:10604.

3. Wei Zhang, Yuying Han, Feng Yang, Lijun Guan, Fuping Lu, Shuhong Mao, Kangming Tian*, Mingdong Yao*, Hui-Min Qin*. A customized self-assembled synergistic biocatalyst for plastic depolymerization. Journal of Hazardous Materials. 2024, 477:135380.

4. Mengying Shan, Zhenlu Li, Herong Wang, Yi Shi, Qi Gao, Ying Wang , Wenhai Xiao*, Mingdong Yao*. Engineered β-carotene hydroxylase with excellent thermostability promotes zeaxanthin production in yeast. Journal of Agricultural and Food Chemistry. 2025, 73(20):12319-12327.

5. Kui Zhou, Chao Yu, Nan Liang, Wenhai Xiao, Ying Wang, Mingdong Yao*, Yingjin Yuan. Adaptive Evolution and metabolic engineering boost lycopene production in Saccharomyces cerevisiae via enhanced precursors supply and utilization. Journal of Agricultural and Food Chemistry. 2023,71:3821−3831.

6. Tongqing Yang, Yixun Jiang, Tianyu Dong, Haoyu Liu, Ying Wang, Wenhai Xiao*, Mingdong Yao*. Engineering the cytochrome P450 to enhance parthenolide production in Saccharomyces cerevisiae. Synth Syst Biotechnol. 2025, 10(3):950-958.

7. Guo-Zhen Jiang#, Ming-Dong Yao#, Ying Wang, Liang Zhou, Tian-Qing Song, Hong Liu, Wen-Hai Xiao*, Ying-Jin Yuan. Manipulation of GES and ERG20 for geraniol overproduction in Saccharomyces cerevisiae. Metabolic Engineering, 2017(41): 57-66.

8. Mengying Shan#, Mingdong Yao#, Nan Liang, Herong Wang, Nan Wu, Ying Wang, Wenhai Xiao, and Ying- jin Yuan. One-Pot Efficient bioconversion of crocetin from zeaxanthin via a dual-enzyme system. ACS Sustainable Chemistry & Engineering. 2023, 11: 8615−8623.