个人简介：

基本信息：副研究员，硕士生导师。

电子邮箱：guoxc2024@foxmail.com。

研究方向：核酸功能材料，合成生物学

个人介绍：博士学历，毕业于天津大学生物化工专业。

研究领域：

面向生命大健康对生物材料的应用需求，致力于智能核酸功能材料组装与创制，用于生物功能调控和疾病精准治疗策略开发。

学术成就：

先后主持国家自然科学基金面上项目和青年项目、中国博士后面上项目、中科院特别研究助理资助项目，参与国家重点研发计划子课题等项目。在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Sci. Adv.、Adv. Mater.、Adv. Funct. Mater.、ACS Synth. Biol.等国际期刊发表论文20余篇。申请中国发明专利9项，获批授权5项。担任《食品研究与开发》和《食品，营养与健康》的青年编委，担任ACS nano、Nanoscale等杂志审稿人。

代表性文章：

1.Xiaocui Guo^#, Mengyu Guo#, Rong Cai*, Mingdi Hu, Le Rao, Wen Su, He Liu, Fene Gao, Xiaoyu Zhang, Jing Liu*, Chunying Chen*. mRNA compartmentalization via muti-module DNA nanostructure assembly augments the immunogenicity and efficacy of cancer mRNA vaccine. Science Advances, 2024, 10(47), eadp3680.

2.Xun You, Rui Zhang, Qingxuan Zeng, Tianshuang Xia, Nachuan Song, Mingxing Liu, Xiaocui Guo*, Chi Yao*, Dayong Yang*. Hyaluronic Acid-Coated DNA Nanoflowers as Smart Nanocarriers for Deep Tumor Penetration and Enhanced Gene Therapy in Pancreatic Cancer, Advanced Functional Materials, 2026, e31547.

3.Xiaocui Guo^#, Feng Li#, Lihui Bai, Wenting Yu, Xue Zhang, Yi Zhu, Dayong Yang*. Gene circuit compartment on nano-interface facilitating cascade gene expression. Journal of the American Chemical Society, 2019, 141(48), 19171-19177.

4.Xiaocui Guo^#, Feng Li#, Chunxia Liu, Yi Zhu, Nannan Xiao, Zi Gu, Dan Luo, Jianhui Jiang, Dayong Yang*. Construction of organelle-like architecture via dynamic DNA assembly in living cells, Angewandte Chemie International Edition, 2020, 59(46), 20651-20658.

5.Yanfei Guo#, Peiran Li #, Xiaocui Guo*, Chi Yao*, Dayong Yang*. Synthetic nanoassemblies for regulating organelles: from molecular design to precision therapeutics. ACS Nano, 2024, 18(44), 30224-30246.