1、个人简介
基本信息：
职称：副研究员
邮箱：sjzhou@tju.edu.cn
研究方向: 合成生物学、基因组设计合成、柔性细胞工厂
个人介绍：副研究员、硕士生导师，2015年本科毕业于天津大学，2021年博士毕业于天津大学合成生物学专业（直博）。合成生物技术全国重点实验室任务办主任、天津大学合成生物前沿研究院副院长。入选天津大学“启明计划”等人才称号；中国化工学会生物化工青年学者工作委员会委员。招生专业：合成生物学/制药工程/生物工程/生物与医药。
2、研究领域
主要研究方向合成生物学、 基因组设计合成、柔性细胞工厂等。
3、学术成就
在 Science、National Science Review、Chemical Society Reviews、Scientia Sinica Vitae等期刊发表论文10余篇， 主持国家自然科学基金青年、国家重点研发专项子课题、JKW课题项目等多项国家级项目，总经费超1千万元。
4、代表性文章
(1) Sijie Zhou#, Yi Wu#, Ze-Xiong Xie, Bin Jia, Ying-Jin Yuan*. Directed genome evolution driven by structural rearrangement techniques. Chemical Society Reviews, 2021, 2021(50): 12788-12807. (Top期刊)
(2) Sijie Zhou#, Yi Wu#, Yu Zhao, Zhen Zhang, Limin Jiang, Lin Liu, Yan Zhang, Jijun Tang, Ying-Jin Yuan*. Dynamics of synthetic yeast chromosome evolution shaped by hierarchical chromatin organization. National Science Review, 2023, 10(5). (Top期刊)
(3) Wangyue Xu, Yue Teng, Sijie Zhou*, Towards the first synthetic eukaryotic cell. Biosafety and Health, 2024, BSHEAL-D-24-00043. (Q1)
(4) Sijie Zhou#, Junyanrui Li#, Xichen Cui, Ying Wang, Ying-Jin Yuan*. Inter-chromosomal insertions into wild-type chromosomes induced by SCRaMbLE. Frontiers of Chemical Science and Engineering, 2024. 18(9): 107. (Q2)
(5) Tuoyu Liu#, Sijie Zhou, Tao Wang, Yue Teng*. Cyberbiosecurity: Advancements in DNA-based information security. Biosafety and Health, 2024, 6:251–256. (Q1)
(6) Yi Wu, Bing-Zhi Li, Meng Zhao, Leslie A Mitchell, Ze-Xiong Xie, Qiu-Hui Lin, Xia Wang, Wen-Hai Xiao, Ying Wang, Xiao Zhou, Hong Liu, Xia Li, Ming-Zhu Ding, Duo Liu, Lu Zhang, Bao-Li Liu, Xiao-Le Wu, Fei-Fei Li, Xiu-Tao Dong, Bin Jia, Wen-Zheng Zhang, Guo-Zhen Jiang, Yue Liu, Xue Bai, Tian-Qing Song, Yan Chen, Sijie Zhou, Rui-Ying Zhu, Feng Gao, Zheng Kuang, Xuya Wang, Michael Shen, Kun Yang, Giovanni Stracquadanio, Sarah M Richardson, Yicong Lin, Lihui Wang, Roy Walker, Yisha Luo, Ping-Sheng Ma, Huanming Yang, Yizhi Cai, Junbiao Dai, Joel S Bader, Jef D Boeke, Ying-Jin Yuan*. Bug mapping and fitness testing of chemically synthesized chromosome X. Science, 2017, 355(6329): 0-eaaf4706.
(7) Yao Xiong, Hui Zhang, Sijie Zhou, Lu Ma, Wenhai Xiao, Yi Wu*, and Ying-Jin Yuan. Structural Variations and Adaptations of Synthetic Chromosome Ends Driven by SCRaMbLE in Haploid and Diploid Yeasts. ACS Synthetic Biology, 2023, 12 (3): 689-699.
(8) Jianping Kang, Jieyi Li, Zhou Guo, Sijie Zhou, Shuxin Su, Wenhai Xiao, Yi Wu*, Yingjin Yuan. Enhancement and mapping of tolerance to salt stress and 5-fluorocytosine in synthetic yeast strains via SCRaMbLE. Synthetic and Systems Biotechnology, 2022, 7 (3): 869-877.
(9) Peixia Wang, Hui Xu, Hao Li, Hebing Chen, Sijie Zhou, Fangfang Tian, Bing-Zhi Li, Xiaochen Bo, Yi Wu, Ying-Jin Yuan*. SCRaMbLEing of a Synthetic Yeast Chromosome with Clustered Essential Genes Reveals Synthetic Lethal Interactions. ACS Synthetic Biology, 2020, 9 (5): 1181-1189.
(10) 周嗣杰,张一平,周晓,田金强,元英进*.科技创新与产业创新融合的典范: 我国合成生物学的演进路径与战略抉择[J].中国科学: 生命科学, 2025, 55: 1957–1967.
