张相宇 助理研究员

邮箱：xiangyu@tju.edu.cn

研究方向：抗冻蛋白分子设计及应用

毕业于哈尔滨工业大学（本科），天津大学（硕博），为生物化工专业博士。聚焦材料合成生物学，长期从事抗冻分子设计及应用研究。设计合成了新型高效抗冻多肽、抗冻蛋白及抗低温材料，应用于重要生物样本（细胞、血液、微生物菌株）的超低温冷冻保存，可替代目前具有毒副作用的二甲基亚砜、甘油等有机溶剂保护剂，取得了显著的成果。相关成果以第一作者或通讯作者在J. Am. Chem. Soc.（2篇）， ‌ACS Appl. Mater. Interfaces（2篇）, Ind. Eng. Chem. Res.，J. Mater. Chem. A.， J. Mater. Chem. B.，Biomacromolecules 等国际知名期刊上发表。

主持国家自然科学基金青年项目（C类），天津市青年基金等项目。申请专利 12 项，已授权 2 项。基于相关成果制备得到高效细胞冻存保护剂，用于 T 细胞的冷冻保存，已与公司合作转化。

代表性文章：

1.Xiangyu Zhang^#, Jing Yang^#, Yunqing Tian^# and Lei Zhang*. Precise de novo design principle of antifreeze peptides. Journal of the American Chemical Society, 2025, 147(21):17682-17688.

2.Xiangyu Zhang^#, Herong Wang^#, Qingsi Li^#, Zhaoxu Yin, Haishan Qi, Jing Yang, Xiaodong Wang, Wenhai Xiao*, and Lei Zhang*. Development of organogels for live Yarrowia lipolytica encapsulation. Journal of the American Chemical Society, 2022, 144(23): 10251-10258.

3.Mengxian Guo^#, Feng Shen^#, Andrew B. Zhu, Xiangyu Zhang* and Lei Zhang*. AFP-based anti-icing coatings: present challenges and future opportunities. Journal of Materials Chemistry A, 2025, 13, 32104-32110.

4.Xinmeng Liu^#, Liming Zhang^#, Yu Lin^#, Xinyang Pang, Jing Yang, Yongjian Li, Xiangyu Zhang* and Lei Zhang*. Low-concentration vitrification agent based on polyglutamic acid and nanowarming for porcine blood vessel cryopreservation. ACS Applied Materials & Interfaces, 2025, 17(22):32054-32065.

5.Feng Shen^#, Xiaoying Jiang^#, Andrew B. Zhu, Haoyu Yang, Xiangyu Zhang* and Lei Zhang*. Development of low-immunogenic AFPs for cell cryopreservation by hydrophilic modification. Langmuir, 2025, 41(30):20154-20160.

6.Xiangyu Zhang^#, Haishan Qi^#, Jing Yang, Xuan Chen, and Lei Zhang*. Development of low immunogenic antifreeze peptides for cryopreservation. Industrial & Engineering Chemistry Research, 2023, 62(31): 12063-12072.